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Stereoselective access to trisubstituted fluorinated alkenyl thioethers

Catalysis Science & Technology 2017,7, 1921-1927

We report the first copper-catalyzed olefinic ethoxy carbonyl difluoromethylation of alkenyl thioethers via direct C–H bond functionalization using BrCF2COOEt. The developed methodology allows the preparation of trisubstituted olefins with a controlled stereochemistry. A mechanistic study is reported and a radical mechanism is revealed.

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