## Analytical calculation of the solvent‐accessible surface area and its nuclear gradients by stereogra

DOI: 10.1002/jcc.26191 Journal of Computational Chemistry In this article, we explore an alternative to the analytical Gauss–Bonnet approach for computing the solvent‐accessible surface area (SASA) and its nuclear gradients. These two key quantities are required to evaluate the nonelectrostatic contribution to the solvation energy and its nuclear gradients in implicit solvation models. We extend a previously proposed analytical approach for finite systems based on the stereog